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Alternatively, PGC-1 may mediate the expression of motor proteins in spinal cord motoneurons and thus modulate movement disorders in an animal model of PD through the stimulation of the upstream promoter of the mitochondrial fusion-associated protein Mfn2 (Mou et al., 2021

188 Lesinurad (RDEA594) Lesinurad is a common URAT1 inhibitor that influences the serum uric acid concentration through the inhibition of URAT1 and OAT4